An alternative form of melarsoprol in sleeping sickness: is an old drug always the best basis for a new one?

作者: Christian Burri

DOI: 10.1016/J.PT.2012.06.002

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摘要: The almost lifelong efforts of Professor Peter Kennedy to improve the situation patients suffering from sleeping sickness must be lauded. He has published a number important and innovative papers on neurology pathogenesis human African trypanosomiasis (HAT). Recently, his group turned towards treatment brought out paper an alternative formulation melarsoprol for second stage [1].

参考文章(4)
Peter G.E. Kennedy, An alternative form of melarsoprol in sleeping sickness. Trends in Parasitology. ,vol. 28, pp. 307- 310 ,(2012) , 10.1016/J.PT.2012.05.003
P. P. SIMARRO, J. FRANCO, A. DIARRA, J. A. RUIZ POSTIGO, J. JANNIN, Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis. Parasitology. ,vol. 139, pp. 842- 846 ,(2012) , 10.1017/S0031182012000169
Jean Rodgers, Amy Jones, Stéphane Gibaud, Barbara Bradley, Christopher McCabe, Michael P. Barrett, George Gettinby, Peter G. E. Kennedy, Melarsoprol Cyclodextrin Inclusion Complexes as Promising Oral Candidates for the Treatment of Human African Trypanosomiasis PLoS Neglected Tropical Diseases. ,vol. 5, pp. e1308- ,(2011) , 10.1371/JOURNAL.PNTD.0001308