Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens-An Insight From Translational Studies.
作者： Branka Šošić-Jurjević , Vladimir Ajdžanović , Dragana Miljić , Svetlana Trifunović , Branko Filipović
DOI: 10.3390/IJMS21062024
关键词:
摘要: Estrogen signaling plays an important role in pituitary development and function. In sensitive rat or mice strains of both sexes, estrogen treatments promote lactotropic cell proliferation induce the formation adenomas (dominantly prolactin growth-hormone-secreting ones). male patients receiving estrogen, treatment does not necessarily result hyperplasia, hyperprolactinemia adenoma development. this review, we comprehensively analyze mechanisms action upon their application animal models comparing it with available data human subjects. Sex-specific molecular targets (PRL) cells are highlighted context proliferative secretory activity. addition, putative effects estradiol on cellular/tumor microenvironment contribution postnatal progenitor/stem transdifferentiation processes to prolactinoma have been analyzed. Finally, estrogen-induced morphological hormone-secreting changes thyrotropic (TSH) adrenocorticotropic (ACTH) discussed, as well thyroid and/or glucocorticoid hormones development, based current scarce literature.
mdpi.com
scilit.net参考文章(142)
Iain Phillips, Syed IA Shah, Trinh Duong, Paul Abel, Ruth E Langley, None, Androgen Deprivation Therapy and the Re-emergence of Parenteral Estrogen in Prostate Cancer. Oncology & Hematology Review. ,vol. 10, pp. 42- 47 ,(2014) , 10.17925/OHR.2014.10.1.42
H.M. Gaudet, S.B. Cheng, E.M. Christensen, E.J. Filardo, The G-protein coupled estrogen receptor, GPER: The inside and inside-out story. Molecular and Cellular Endocrinology. ,vol. 418, pp. 207- 219 ,(2015) , 10.1016/J.MCE.2015.07.016
Dipak K. Sarkar, Genesis of prolactinomas: studies using estrogen-treated animals. Frontiers of Hormone Research. ,vol. 35, pp. 32- 49 ,(2006) , 10.1159/000094307
Paulo Henrique Gonzales, Lisiane Cervieri Mezzomo, Nelson Pires Ferreira, Adriana Vial Roehe, Maria Beatriz Fonte Kohek, Miriam da Costa Oliveira, Aromatase P450 expression in human pituitary adenomas. Neuropathology. ,vol. 35, pp. 16- 23 ,(2015) , 10.1111/NEUP.12145
Long Jin, Ricardo V. Lloyd, Jiangyue Song, Effects of Estradiol on Prolactin and Growth Hormone Messenger RNAs in Cultured Normal and Neoplastic (MtT/W15 and GH3) Rat Pituitary Cells Cancer Research. ,vol. 49, pp. 1247- 1253 ,(1989)
S Yoshida, T Kato, H Yako, T Susa, L‐Y Cai, M Osuna, K Inoue, Y Kato, None, Significant Quantitative and Qualitative Transition in Pituitary Stem / Progenitor Cells Occurs during the Postnatal Development of the Rat Anterior Pituitary Journal of Neuroendocrinology. ,vol. 23, pp. 933- 943 ,(2011) , 10.1111/J.1365-2826.2011.02198.X
L. STEPHEN FRAWLEY, F. R. BOOCKFOR, Mammosomatotropes : presence and functions in normal and neoplastic pituitary tissue. Endocrine Reviews. ,vol. 12, pp. 337- 355 ,(1991) , 10.1210/EDRV-12-4-337
Sara Bondioni, Anita R. Angioni, Sabrina Corbetta, Marco Locatelli, Stefano Ferrero, Emanuele Ferrante, Giovanna Mantovani, Luca Olgiati, Paolo Beck-Peccoz, Anna Spada, Andrea G. Lania, Effect of 9-cis Retinoic Acid on Dopamine D2 Receptor Expression in Pituitary Adenoma Cells Experimental Biology and Medicine. ,vol. 233, pp. 439- 446 ,(2008) , 10.3181/0704-RM-94
M. Victoria Recouvreux, Lara Lapyckyj, M. Andrea Camilletti, M. Clara Guida, Ana Ornstein, Daniel B. Rifkin, Damasia Becu-Villalobos, Graciela Díaz-Torga, Sex Differences in the Pituitary Transforming Growth Factor-β1 System: Studies in a Model of Resistant Prolactinomas Endocrinology. ,vol. 154, pp. 4192- 4205 ,(2013) , 10.1210/EN.2013-1433
Mariagiovanna Filippella, Françoise Galland, Michèle Kujas, Jacques Young, Antongiulio Faggiano, Gaetano Lombardi, Annamaria Colao, Geri Meduri, Philippe Chanson, Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study Clinical Endocrinology. ,vol. 65, pp. 536- 543 ,(2006) , 10.1111/J.1365-2265.2006.02630.X