P53 overexpression predicts poor chemosensitivity to high‐dose 5‐fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection

摘要: Our study aims to further clarify the prognostic significance of p53 overexpression in stage IV colorectal cancer. Between January 1994 and June 1997, we recruited 144 patients with cancers for our study, based on appropriate eligibility criteria. The were nonrandomly allocated 2 treatment groups either or without high-dose 5-fluorouracil plus leucovorin chemotherapy (HDFL: 5-Fu: 2,600 mg/m2 300 mg/m maximum 500 mg). Each group was divided into subgroups according status overexpression. Therefore, 4 designated as (overexpression) HDFL (+), n = 65; (normal) 37; (−), 27; 15, respectively. All prospectively followed until April 2001. There no significant difference background clinicopathologic data these (p > 0.05). Multivariate analysis various factors whole indicated that age ≥60 years, poor differentiation, mucin production, CEA >100 ng/ml, independent We thus concluded poorer prognosis associated their chemosensitivity rather than more biologic aggressiveness. © 2001 Wiley-Liss, Inc.