IgA Nephropathy and Related Diseases
作者： Steven N. Emancipator , Jiri Mestecky , Michael E. Lamm
DOI: 10.1016/B978-012491543-5/50096-6
关键词:
摘要: IgA nephropathy (IgAN) is caused by the accumulation of IgA-immune complexes (IC) in glomeruli. The enzymes that assemble glycan side chains on various glycoproteins and glycolipids are highly sensitive to external stimuli, including cytokines. Some Th2 cytokines dominate cellular immune responses Peyer's patches elicit increased production also promote hypogalactosylation both O -linked N glycans, at least vitro. In patients with IgAN, synthesis (increased ks and/or ks') represents humoral mucosal antigens. within single samples IC from individual IgAN not only polyclonal but polyspecific, is, includes antibodies bind several antigens, complexed antigens often originate distinct sources. Furthermore, implicated associated portals entry, temporal associations between antigen entry (via dietary exposure infection) exacerbations nephritis well established. Thus, glomerular deposits represent combined synthesized large part (or mucosally derived) plasma cells.
elsevier.com
sci-hub.st 参考文章(221)
Hitoo Iwase, Atsushi Tanaka, Yoshiyuki Hiki, Tohru Kokubo, Ikuko Ishii-Karakasa, Joji Nishikido, Yutaka Kobayashi, Kyoko Hotta, Application of matrix-assisted laser desorption ionization time-of-flight mass spectrometry to the analysis of glycopeptide-containing multiple O-linked oligosaccharides Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 709, pp. 145- 149 ,(1998) , 10.1016/S0378-4347(98)00050-4
K. N. LAI, J. C. K. LEUNG, P. K. T. LI, S. F. LUI, Cytokine production by peripheral blood mononuclear cells in IgA nephropathy. Clinical and Experimental Immunology. ,vol. 85, pp. 240- 245 ,(2008) , 10.1111/J.1365-2249.1991.TB05712.X
Jiri MESTECKY, Milan TOMANA, Structural heterogeneity of glycans in IgA molecules: Implications for IgA nephropathy Nephrology. ,vol. 3, ,(1997) , 10.1111/J.1440-1797.1997.TB00280.X
Russell P. Hall, Irene Stachura, Joseph Cason, Theresa L. Whiteside, Thomas J. Lawley, IgA-containing circulating immune complexes in patients with IgA nephropathy The American Journal of Medicine. ,vol. 74, pp. 56- 63 ,(1983) , 10.1016/0002-9343(83)91118-X
Jiri MESTECKY, Milan TOMANA, Karel MATOUSOVIC, Karel KONECNY, Jiri Radl, Bruce A. JULIAN, Heterogeneity of carbohydrate moieties of IgA1 molecules from IgA nephropathy patients and normal individuals Nephrology. ,vol. 3, pp. 85- 89 ,(1997) , 10.1111/J.1440-1797.1997.TB00195.X
Steven C. Diven, Carlton R. Caflisch, Dianne K. Hammond, Paul H. Weigel, Janet A. Oka, Randall M. Goldblum, IgA induced activation of human mesangial cells: Independent of FcαR1 (CD 89) Kidney International. ,vol. 54, pp. 837- 847 ,(1998) , 10.1046/J.1523-1755.1998.00054.X
K S Tung, A J Woodroffe, T D Ahlin, R C Williams, C B Wilson, Application of the solid phase C1q and Raji cell radioimmune assays for the detection of circulating immune complexes in glomerulonephritis. Journal of Clinical Investigation. ,vol. 62, pp. 61- 72 ,(1978) , 10.1172/JCI109115
C. Cunningham-Rundles, W. E. Brandeis, R. A. Good, N. K. Day, Milk precipitins, circulating immune complexes, and IgA deficiency. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 75, pp. 3387- 3389 ,(1978) , 10.1073/PNAS.75.7.3387
F. Bryson Waldo, Systemic immune response after mucosal immunization in patients with IgA nephropathy. Journal of Clinical Immunology. ,vol. 12, pp. 21- 26 ,(1992) , 10.1007/BF00918269
G. Rostoker, M.A. Pech, M. Petit-Phar, A. BenMaadi, S. Cholin, P. Lang, J.M. Dubert, B. Weil, G. Lagrue, Mucosal immunity in adult primary glomerulonephritis. I. Evaluation of salivary IgA subclasses and components. Nephron. ,vol. 54, pp. 42- 46 ,(1990) , 10.1159/000185808