Distribution of airway contractile responses within the major diameter bronchi during exogenous bronchoconstriction.
作者： Julian Solway , Alan R. Leff , Nilda M. Munoz , Takanobu Shioya , Matthew Mack
DOI: 10.1164/ARRD.1987.135.5.1105
关键词:
摘要: The distribution of bronchoconstrictor responses within airway generations zero to 6 was studied by tantalum bronchography during exogenous bronchoconstriction with methacholine (MCh), prostaglandin F2α(PGF2α), norepinephrine (NE), and the thromboxane mimetic U-46619 [(15S)-hydroxyl-11α,9α-(epoxymethano)prosta-5Z,13E-dienoic acid] in 12 mongrel dogs undergoing vagotomy beta-adrenergic blockade. Dose-response curves each agonist were generated random order, bronchograms simultaneous measurements pulmonary resistance (Rl) dynamic compliance (Cdyn) obtained at plateau response dose after intravenous (iv) infusion. At 5 × 10−7 mol/kg, NE (after β-adrenergic blockade) caused an increase 254 ± 27.3%, PGF2α 368 50.0%, 522 98.5%, MCh 1,204 173% baseline Rl. However, diameter changes major airways varied substantially for agonist. Methacholine substantial contrac...
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