Tumor Suppressive Functions of p53

摘要: The majority of human cancers acquire mutations that abrogate the p53 tumor suppressor network and, as a consequence, is one most extensively studied proteins in cancer research. Because its potent suppressive activity, it widely assumed molecular understanding action will produce fundamental insights into natural processes limit tumorigenesis and may identify key targets for therapeutic intervention. functions largely transcription factor, can trigger variety antiproliferative programs by activating or repressing effector genes. Despite significant body literature detailing biochemical biological p53, much remains to be elucidated. Indeed, complex enigmatic relevant. It goal this article, written 30 years after discovery present concise review role highlight context-dependent nature target-gene functions.