Role of circulating factors in cardiac aging.
作者： Antonio Cannatà , Gabriella Marcon , Giovanni Cimmino , Luca Camparini , Giulio Ciucci
关键词:
摘要: Worldwide increase in life expectancy is a major contributor to the epidemic of chronic degenerative diseases. Aging, indeed, simultaneously affects multiple organ systems, and it has been hypothesized that systemic alterations regulators tissue physiology may regulate this process. Cardiac aging itself risk factor for cardiovascular diseases and, because intimate relationship with brain, contribute neurodegenerative disorders. Blood-borne factors play role complex still elusive A number studies, mainly based on revival parabiosis, surgical technique very popular during 70s 20 th century study effect shared circulation two animals, have indeed shown potential humoral can control process different tissues. In article we review circulating aging. better understanding these mechanisms provide new insights novel therapeutic opportunities age-related
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