Preventive effects of multisensory rehabilitation on development of cognitive dysfunction following systemic inflammation in aged rats

摘要: Systemic inflammation can trigger transient or longer-lasting cognitive impairments, particularly in elderly patients. However, its pathogenesis has not been sufficiently clarified. In this study, we explored the potential effects of multisensory rehabilitation on dysfunction following systemic using an animal model. Aged male Wister rats were randomly injected intraperitoneally with either saline (control) lipopolysaccharide (LPS; 5 mg/kg). After injection, both groups assigned to two housing conditions (n = 8 each condition): a standard cage environment (SC group) early (ER group). Cognitive function was examined after 7 days environmental condition novel object recognition test. SC group, LPS-treated showed impaired compared control animals. These memory deficits positively correlated levels tumor necrosis factor (TNF)-α and interleukin (IL)-1β hippocampus. On other hand, ER neither impairment nor increase hippocampal TNF-α IL-1β found. results imply that (ER) intervention may be effective preventing via anti-neuroinflammatory effects.