A novel pregnane-type alkaloid from Pachysandra terminalis inhibits methicillin-resistant Staphylococcus aureus in vitro and in vivo.
作者： Hui Zhao , Xiao-Yang Wang , Ming-Kai Li , Zheng Hou , Ying Zhou
DOI: 10.1002/PTR.5261
关键词:
摘要: A new kind of pregnane-type alkaloid, 20α-dimethylamino-3β-senecioylamino-16β-hydroxy-pregn-5-ene (K-6), was isolated from Pachysandra terminalis Sieb. et Zucc., and its antibacterial activity against MRSA MRSE evaluated. We found that K-6 showed effects with minimum inhibitory concentration values (25 mg/L), but did not induce antibiotic resistance in bacteria easily. The administration dose-dependently improved the animal survival rate mice infected MRSA, rates 36.34% 66.67% low-dose high-dose groups, respectively. protective were associated reduction bacterial titers blood morphological amelioration tissues. Scanning transmission electron microscopy analyses indicated cytoplasm shrink cells led to noticeable gaps between cell membrane cytoplasm, severely damaged resulted leakage intracellular content, which ultimately caused lethal effect on bacteria. These findings demonstrated is a potential agent MRSE. Copyright © 2014 John Wiley & Sons, Ltd.
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