Lesions of the fornix but not the entorhinal or perirhinal cortex interfere with contextual fear conditioning

摘要: The effects of entorhinal cortex lesions, combined and perirhinal fornix lesions on the conditioning fear responses (freezing) to contextual stimuli were examined using a procedure known produce hippocampal-dependent conditioning. Lesions or plus did not disrupt conditioning, but did. None affected an explicit conditioned stimulus. Given that is primary linkage between neocortex hippocampus with subcortical structures, inputs outputs appear be sufficient mediate As result, presumption neocortical information required for perhaps other functions, should reevaluated.