Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases.
作者： Ignazio Barbagallo , Fabio Galvano , Alessandro Frigiola , Francesco Cappello , Graziano Riccioni
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摘要: Abstract Significance: Many physiological effects of natural antioxidants, their extracts or major active components, have been reported in recent decades. Most these compounds are characterized by a phenolic structure, similar to that α-tocopherol, and present antioxidant properties demonstrated both vitro vivo. Polyphenols may increase the capacity endogenous defenses modulate cellular redox state. Such wide-ranging consequences for growth differentiation. Critical Issues: The majority vivo studies conducted so far attributed protective effect bioactive polyphenols chemical reactivity toward free radicals prevent oxidation important intracellular components. One possible molecular mechanism is nuclear factor erythroid 2-related (Nrf2) activation, which turn regulates number detoxification enzymes. Recent Ad...
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