Insight into the peopling of mainland southeast Asia from thai population genetic structure.

摘要: There is considerable ethno-linguistic and genetic variation among human populations in Asia, although tracing the origins of this diversity complicated by migration events. Thailand at center Mainland Southeast Asia (MSEA), a region within that has not been extensively studied. Genetic substructure may exist Thai population, since waves from southern China throughout its recent history have contributed to substantial gene flow. Autosomal SNP data were collated for 438,503 markers 992 individuals. Using available self-reported regional origin, four subpopulations genetically distinct each other Asian resolved Neighbor-Joining analysis using 41,569 marker subset. an independent Principal Components-based unsupervised clustering approach, major MSEA which bias was apparent. A ancestry component common these distinguishes them subpopulations. On hand, admixed with ancestries, particular one shared Chinese. Subpopulation only individuals complete set subpopulations, are distributed differently across Thailand. Sino-Thai subpopulation concentrated Central Thailand, constituted minority otherwise diverse region. Among most highly differentiated distinguish several map regions known affect phenotypic traits such as skin pigmentation susceptibility diseases. The patterns elucidated important implications evolutionary medical genetics. structure reflect contributions different migrants MSEA. information will also be association studies account population-structure confounding effects.