A randomized comparative trial of chemotherapy and irradiation therapy for stage ii breast cancer

摘要: One hundred fifty-eight evaluable patients with Stage II carcinoma of the breast positive lymph nodes were treated either adjuvant chemotherapy or irradiation therapy followed by chemotherapy. Patients randomized to test effectiveness L-phenylalanine mustard (L-PAM) and without postoperative (R.T.) against cyclophosphamide, 5-fluorouracil, methotrexate (CMF) in decreasing frequency recurrence. No significant difference was observed between L-PAM as compared R.T. plus (P = 0.85). The CMF support alone 0.04). recurrence showed no difference. A comparison only regimens an advantage over 0.05). Both delay starting decrease percent optimal drug dosage during first six cycles are factors that may influence high relapse groups. Of four treatments, has lowest