Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment

摘要: As the population of Western world is aging, there increasing awareness age-related impairments in cognitive function and a rising interest finding novel approaches to preserve cerebral health. A special collection articles The Journals Gerontology: Biological Sciences Medical brings together information different aspects brain from latest developments field neurodegenerative disorders microvascular mechanisms decline. It emphasized that although cellular changes occur within aging neurons have been widely studied, more research required as new signaling pathways are discovered can potentially protect cells. New avenues for targeting senescence, epigenetics, endocrine also discussed. Based on current literature it clear understanding reducing risk neurological disease with age requires searching treatment options beyond neuronal function. Thus, comprehensive need be developed address multiple, interrelated aging. Attention brought importance maintenance cerebromicrovascular health, restoring neuroendocrine balance, pressing funding innovative into interactions neuronal, neuroendocrine, inflammatory impairment, Alzheimer's disease.