Site-specific Metastasis of Mouse Melanomas and a Fibrosarcoma in the Brain or Meninges of Syngeneic Animals

摘要: Different subpopulations of cells from two different murine melanomas (K-1735 and B16) a fibrosarcoma (UV-2237) were injected into the internal carotid artery anesthetized syngeneic mice. Despite common route tumor cell injection, lesions in brain unique to each type developed at sites brain. Gross histological examinations revealed that derived K-1735 melanoma produced only parenchymal lesions, B16 meninges ventricles, UV-2237 throughout This site specificity for growth was not due initial arrest microvasculature regions-areas as evidenced by detailed studies with radiolabeled cells. The this experimental metastasis random correlated well clinical situation. exact interactions microenvironments need further elucidation.