The creation of the Comparative Oncology Trials Consortium Pharmacodynamic Core: Infrastructure for a virtual laboratory

摘要: The National Cancer Institute–Comparative Oncology Trials Consortium (NCI–COTC) aims to inform the development path of novel drugs and biologicals for human cancer patients through their evaluation in dogs with neoplasia. advent sophisticated clinical trials veterinary medicine requires additional infrastructure evaluate tissue fluid end-points vital questions relating drug activity, targeting toxicity. Pharmacokinetic pharmacodynamic necessitate a centralized laboratory quality controlled assay execution. Establishing COTC Pharmacodynamic Core (PD Core) has addressed need uniform end-point analysis by serving as virtual that capitalizes on expertise community investigators. Veterinary biomarker validation is secondary benefit these efforts. PD exemplifies construction successful within research line advances technology focused improving health life both animal patients.