Effectiveness and safety of hypertonic saline inhalation combined with exercise training in patients with chronic obstructive pulmonary disease: a randomized trial.
作者： Alvaro Nagib Atallah , Silvia R Valderramas
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摘要: BACKGROUND: Inhaled hypertonic saline is used for bronchial challenge and sputum induction in patients with chronic obstructive pulmonary disease (COPD). We studied the effects of aerosol inhalation before each exercise session an 8-week rehabilitation program. METHODS: This was a double-blind randomized parallel controlled trial, conducted at outpatient clinic. Sixty-eight subjects COPD (mean age 67 6.5 y, percent predicted FEV1 47 21) were to inhale either 3% (34 subjects) or normal program that had 3 sessions per week. measured 6-min walk distance, dyspnea, quality life (with Medical Outcomes Study 36-item short-form health survey). RESULTS: After program, both groups’ mean distance significantly increased: from 195 92 mt o 251 97 m( P < .001) hypertonic-saline group, 237 93 441 121 m normal-saline group (P .001). The greater improvement than Dyspnea score improved 3.1 0.9 2.3 0.8 .01) 3.5 0.2 1.0 group. Quality also improved, except physical-functioning social aspect domains Adverse (cough bronchospasm) occurred 4 (12%) CONCLUSIONS: saline. Hypertonic associated adverse
参考文章(40)
Bruce K. Rubin, Robert P. Tomkiewicz, Malcolm King, Mucoactive Agents: Old and New Birkhäuser, Basel. pp. 155- 179 ,(1997) , 10.1007/978-3-0348-8960-5_7
Ivone Meinao, Rozana Mesquita Ciconelli, Marcos Bosi Ferraz, Marina Rodrigues Quaresma, Wilton Santos, Traducao para a lingua portuguesa e validacao do questionario generico de avaliacao de qualidade de vida SF-36 (Brasil SF-36) Revista Brasileira De Reumatologia. ,vol. 39, pp. 143- 150 ,(1999)
Martha S. Bayliss, John E. Ware Jr., Susan D. Keller, Anne M. Damiano, Ming Ann Hsu, Thomas F. Goss, Comparison of responses to SF-36 Health Survey questions with one-week and four-week recall periods Health Services Research. ,vol. 32, pp. 367- 384 ,(1997)
Duncan F Rogers, Mucoactive agents for airway mucus hypersecretory diseases. Respiratory Care. ,vol. 52, pp. 1176- 1197 ,(2007)
Bernard McCarthy, Dympna Casey, Declan Devane, Kathy Murphy, Edel Murphy, Yves Lacasse, None, Pulmonary rehabilitation for chronic obstructive pulmonary disease Cochrane Database of Systematic Reviews. ,(2015) , 10.1002/14651858.CD003793.PUB3
Thierry Troosters, Rik Gosselink, Marc Decramer, Six-minute walk test: a valuable test, when properly standardized. Physical Therapy. ,vol. 82, pp. 826- 828 ,(2002) , 10.1093/PTJ/82.8.826
Giovanna E. Carpagnano, M.P. Foschino Barbaro, M. Cagnazzo, G Di Gioia, T Giliberti, C Di Matteo, O Resta, Use of Exhaled Breath Condensate in the Study of Airway Inflammation After Hypertonic Saline Solution Challenge Chest. ,vol. 128, pp. 3159- 3166 ,(2005) , 10.1378/CHEST.128.5.3159
C.J. Hunter, R. Ward, G. Woltmann, A.J. Wardlaw, I.D. Pavord, The safety and success rate of sputum induction using a low output ultrasonic nebuliser web science. ,vol. 93, pp. 345- 348 ,(1999) , 10.1016/S0954-6111(99)90317-7
J RIEDLER, T READE, B BUTTON, CF ROBERTSON, Inhaled hypertonic saline increases sputum expectoration in cystic fibrosis Journal of Paediatrics and Child Health. ,vol. 32, pp. 48- 50 ,(1996) , 10.1111/J.1440-1754.1996.TB01541.X
Donald A. Mahler, Carolyn K. Wells, Evaluation of Clinical Methods for Rating Dyspnea Chest. ,vol. 93, pp. 580- 586 ,(1988) , 10.1378/CHEST.93.3.580