Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals

摘要: Chronic alcohol abuse is associated with changes in stress and reward pathways that could alter vulnerability to emotional craving. This study examines whether chronic altered craving responses. Treatment-engaged, 28-day abstinent alcohol-dependent individuals (ADs; 6F/22M), social drinkers (SDs; 10F/18M) were exposed a brief guided imagery of personalized stressful, alcohol-related neutral-relaxing situation, one condition per session, presented random order across 3 days. Alcohol craving, anxiety emotion ratings, behavioral distress responses, heart rate, blood pressure, salivary cortisol measures assessed. patients showed significantly elevated basal rate levels. Stress cue exposure each produced enhanced persistent state was marked by increased anxiety, negative emotion, systolic pressure and, the case cue, as compared SDs. Blunted stress-induced responses observed AD SD group. These data are first document induce emotion-related alcoholics accompanied dysregulated HPA physiological arousal As laboratory models mood-induced predictive relapse outcomes, implication current treatments targeting decreases cue-induced regulation be benefit improving outcomes.