Attributes of short linear motifs.

摘要: Traditionally, protein–protein interactions were thought to be mediated by large, structured domains. However, it has become clear that the interactome comprises a wide range of binding interfaces with varying degrees flexibility, ranging from rigid globular domains disordered regions natively lack structure. Enrichment for disorder in highly connected hub proteins and its correlation organism complexity hint at functional importance regions. Nevertheless, they have not yet been extensively characterised. Shifting attention proteome might bring us closer elucidating dense complex connectivity interactome. An important class are compact mono-partite, short linear motifs (SLiMs, or eukaryotic (ELMs)). They evolutionarily plastic interact relatively low affinity due limited number residues make direct contact partner. These features confer SLiMs ability evolve convergently mediate transient interactions, which is imperative network evolution maintain robust cell signalling, respectively. The discriminate biologically relevant means different attributes will improve our understanding aid development bioinformatics tools motif discovery. In this paper, curated instances currently available Eukaryotic Linear Motif (ELM) database analysed provide overview defining SLiMs. analyses suggest higher levels conservation than their surrounding residues, frequently convergently, preferentially occur often form secondary structure when bound interaction results advocate searching small groupings relative propensity Finally, most interesting conclusions examined regard consequences.