Emerging diagnostic tests for vitreoretinal lymphoma: a review.

摘要: Vitreoretinal lymphoma, which most commonly is diffuse large B-cell non-Hodgkin in type, a rare cancer with high morbidity and mortality. Making tissue diagnosis of vitreoretinal lymphoma major challenge for clinicians due to biological technical factors. Yet, the delay start treatment may have vision- life-threatening consequences, there considerable interest application molecular assays improve accuracy diagnostic process: detection clonal immunoglobulin heavy-chain rearrangements cells by polymerase chain reaction; measurement vitreous or aqueous interleukin-10 protein levels ocular fluids; identification mutations myeloid differentiation primary response gene 88 tumour cells. In this article, we review historical development current each these methods. We also discuss future opportunities through next-generation sequencing technologies.