Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind study with parallel groups

摘要: In a randomized, double-blind study (n = 58) with parallel groups, the effects of diltiazem (mean dose 329 mg/day) and atenolol 67 on carbohydrate lipoprotein metabolism in hypertensive patients were compared. The mean systolic blood pressure (SBP)/diastolic (DBP) reductions supine position similar satisfactory, 9/11 11/9 mmHg during treatment, respectively. Insulin-mediated glucose uptake, measured euglycaemic insulin clamp technique, decreased from 7.1 to 5.6 mg/kg per min (P 0.05). but not treatment (initial value 6.8, final 6.7 min; P greater than 0.8). Treatment differences between groups statistically significant less During there was slight increase plasma fasting state 0.05) at end an intravenous tolerance test (IVGTT; 0.01), IVGTT Despite increased resistance response small, suggesting inhibition release. peak by 13% concentrations very-low low-density triglycerides increased, whereas high-density cholesterol unaffected treatment. conclusion, no difference antihypertensive diltiazem, sensitivity altered lipid profile, thus possibly increasing risk diabetes mellitus theoretically reducing benefits reduction regard coronary heart disease.