摘要: During development and homeostasis, individual cells must divide, differentiate, migrate, adapt to the environment, or die at appropriate times places. A key deciphering molecular mechanisms by which make these decisions is characterize regulation function of proteins that regulate important changes in gene expression. The family transcription factors contain basic-helix-loop-helix PAS motifs has been shown control many critical developmental events mediate responses certain environmental stimuli. For example, bHLH-PAS play central roles specific neural tissues vasculature, they are core components clock govern circadian rhythms. also integral pathways sense respond hypoxia (low oxygen) xenobiotics (1). Phylogenetic analyses suggest genes arose early animal development, some cases, functions largely conserved across phyla. This review describes a genetic model organism, nematode Caenorhabditis elegans.
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Snorri S. Thorgeirsson, Daniel W. Nebert, The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Advances in Cancer Research. ,vol. 25, pp. 149- 193 ,(1977) , 10.1016/S0065-230X(08)60634-X
G H Perdew, Association of the Ah receptor with the 90-kDa heat shock protein. Journal of Biological Chemistry. ,vol. 263, pp. 13802- 13805 ,(1988) , 10.1016/S0021-9258(18)68314-0
L Aravind, Eugene V Koonin, The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biology. ,vol. 2, pp. 1- 8 ,(2001) , 10.1186/GB-2001-2-3-RESEARCH0007
Tiina Matikainen, Gloria I. Perez, Andrea Jurisicova, James K. Pru, Jennifer J. Schlezinger, Heui-Young Ryu, Jarmo Laine, Toshiyuki Sakai, Stanley J. Korsmeyer, Robert F. Casper, David H. Sherr, Jonathan L. Tilly, Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nature Genetics. ,vol. 28, pp. 355- 360 ,(2001) , 10.1038/NG575
Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter J. Ratcliffe, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature. ,vol. 399, pp. 271- 275 ,(1999) , 10.1038/20459
S Reisz-Porszasz, O Hankinson, M R Probst, R V Agbunag, M S Ong, Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Molecular Pharmacology. ,vol. 44, pp. 511- 518 ,(1993)
W.A. Van Voorhies, S. Ward, Broad oxygen tolerance in the nematode Caenorhabditis elegans The Journal of Experimental Biology. ,vol. 203, pp. 2467- 2478 ,(2000) , 10.1242/JEB.203.16.2467
Masahiro Tohkin, Morio Fukuhara, Guillermo Elizondo, Shuhei Tomita, Frank J. Gonzalez, Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1A. Molecular Pharmacology. ,vol. 58, pp. 845- 851 ,(2000) , 10.1124/MOL.58.4.845
Carol Trent, Nancy Tsung, H Robert Horvitz, EGG-LAYING DEFECTIVE MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS Genetics. ,vol. 104, pp. 619- 647 ,(1983) , 10.1093/GENETICS/104.4.619
J. A. Powell-Coffman, C. A. Bradfield, W. B. Wood, Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 2844- 2849 ,(1998) , 10.1073/PNAS.95.6.2844