ABCC1 polymorphism Arg723Gln (2168G > A) is associated with lung cancer susceptibility in a Chinese population
作者： Ji-Ye Yin , Li-Fang Han , Qiong Huang , Xiao-Jing Xu , Hong-Hao Zhou
DOI: 10.1111/J.1440-1681.2011.05571.X
关键词:
摘要: Summary 1. In a previous in vitro study, we showed that the Arg723Gln (2168G > A) polymorphism significantly ABCC1-induced multidrug resistance. The aim of present study was to further investigate association this with lung cancer susceptibility and chemotherapy response Chinese population. 2. A total 77 patients (54 men, 23 women) 71 cancer-free controls (49 22 were enrolled study. Genomic DNA extracted from peripheral blood all samples genotyped using polymerase chain reaction-restriction fragment length polymorphism. 3. Individuals carrying 723Gln (A) allele have 3.4-fold increased risk (adjusted odds ratio (OR) 3.42; 95% confidence interval (CI) 1.29–9.06; P = 0.013) compared wild-type individuals. Further stratified analysis indicated older individuals (> 50 years) highest OR 4.10; CI 1.25–13.48; P = 0.020). However, no substantial found between patients. 4. In conclusion, ABCC1 appears be potential marker for population, especially people.
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