Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography
作者： Johoon Kim , Peter Chhour , Jessica Hsu , Harold I. Litt , Victor A. Ferrari
DOI: 10.1021/ACS.BIOCONJCHEM.7B00194
关键词:
摘要: Efforts to develop novel cell-based therapies originated with the first bone marrow transplant on a leukemia patient in 1956. Preclinical and clinical examples of treatment strategies have shown promising results across many disciplines medicine, recent advances immune cell for cancer producing remarkable response rates, even patients multiple failures. However, suffer from inconsistent outcomes, motivating search tools that allow monitoring delivery behavior vivo. Noninvasive imaging techniques, also known as tracking, been developed address this issue. These can real-time, quantitative, long-term transplanted cells recipient, providing insight migration, distribution, viability, differentiation, fate, all which play crucial roles efficacy. Understanding these parameters allows optimization choice, route, ...
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