Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria.
作者： David E. Arnot , Anja T.R. Jensen
DOI: 10.1016/B978-0-12-387022-3.00007-0
关键词:
摘要: How immunity to malaria develops remains one of the great unresolved issues in bio-medicine and resolution its various paradoxes is likely be key developing effective vaccines. The basic epidemiological observations are; under conditions intense natural transmission, humans do become immune P. falciparum malaria, but this a slow process requiring multiple disease episodes which many, particularly young children, not survive. Adult survivors are symptoms unless pregnant, can control growth most or all new inoculations. Sterile achieved chronic parasitization apparently healthy adults norm. In article, we analyse best understood "antigenic variation" system, that based on Plasmodium falciparum's PfEMP1-type cytoadhesion antigens, critically review recent literature function multi-gene family parasite variable surface antigens.
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