Neurophysiological aspects of the regulation of serotonin neurons by the orexinergic system

摘要: Orexin (also called hypocretin) is a neurotransmitter that influences central arousal and vigilance state, especially by coupling the level of to energy balance. Localized uniquely neurons with cell bodies in lateral hypothalamus, orexin has widespread projections throughout neuraxis, including raphe nuclei. Dense orexinergic innervation been noted dorsal raphe, where direct axodendritic contacts between fibers serotoninergic processes have also described. depolarizes cells, an effect consistent activation canonical form transient receptor potential channel. Thus, will be integrated other neurotransmitters depolarize cells through this channel, noradrenaline histamine. However, addition action, at higher concentrations GABAergic interneurons reduces glutamatergic release local terminals retrograde endocannabinoid signal. The functional consequences these interactions serotonin remain elucidated, although they are synaptic modification. Hence may modulate influence forebrain as part adaptive response homeostatic disequilibrium.