Effect of n-3 fatty acids on markers of brain injury and incidence of sepsis-associated delirium in septic patients.

摘要: Data regarding immunomodulatory effects of parenteral n-3 fatty acids in sepsis are conflicting. In this study, the effect administration on markers brain injury, incidence sepsis-associated delirium, and inflammatory mediators septic patients was investigated.; Fifty with were randomized to receive either 2 ml/kg/day a lipid emulsion containing highly refined fish oil (equivalent 0.12 mg/kg/day) during 7 days after admission intensive care unit or standard treatment. Markers injury measured 1, 2, 3 7. Assessment for delirium performed daily. The primary outcome difference S-100β from baseline peak level between both intervention control group, compared by t-test. Changes all over time explored groups, fitting generalized estimating equations model.; Mean change 0.34 (95% CI: -0.18-0.85) respectively (P = 0.19). We found no plasma levels S-100β, neuron-specific enolase, interleukin (IL)-6, IL-8, IL-10, C-reactive protein groups time. Incidence 75% 71% (risk 4%, 95% CI -24-31%, P 0.796).; Administration did not affect patients.