Topoisomerases and Carcinogenesis: Topoisomerase IIIα and BLM

摘要: In human cells, Topoisomerase IIIα (Top3α) is the main partner of BLM, Bloom syndrome (BS) helicase. BS constitutes a genetic and clinical model for recessive cancer predisposition study this disease may help to decipher pathways carcinogenesis in general population. The physical functional interactions between BLM Top3α have been extensively studied during last 10 years. Importantly, are part larger complex that includes BLAP75/RMI1 RMI2 interacts with several proteins Fanconi anemia pathway. BLM-Top3α regulates homologous recombination somatic cells prevents formation sister chromatid exchanges (SCEs). also ploidy through role anaphase bridge resolution plays major an alternative telomere maintenance mechanism using (Alternative Lengthening Telomeres) lacking telomerase activity. recent implication some variants TOP3α genes risk population underline importance maintaining genomic stability preventing cancer.