Analysis of sequential changes in major histocompatibility complex expression in human liver grafts after transplantation.

摘要: The expression of class I and II major histocompatibility complex (MHC) antigens in human liver grafts was analyzed 88 biopsies from 22 patients. For the staining MHC antigens, a panel monoclonal antibodies directed against monomorphic determinants molecules an indirect immunoperoxidase method were used. In reference biopsies, expressed on all cell types but only weakly hepatocytes; Kupffer cells, interstitial endothelia. After transplantation, this pattern markedly modified. Increased hepatocytes HLA-DR bile ducts occurred absence clinical rejection. During acute rejection, strongly ducts, further increased. Cytomegalovirus hepatitis caused induction strong also found cholangitis. These findings have number implications for pathophysiology rejection transplanted liver.