Increased severity of obstructive sleep apnea after bedtime alcohol ingestion: diagnostic potential and proposed mechanism of action.

摘要: To assess the effect of 3 oz 80-proof alcohol on frequency and severity obstructive sleep apnea (OSA), we studied six OSA patients healthy subjects 2 nights. During 1st night, when no was given, five demonstrated mild one severe episodes associated with a decline in arterial oxygen saturation to at least 92% (hypoxic event). On 2nd night after ingesting just prior bedtime, all significant increase number and/or hypoxic events compared no-alcohol night. Furthermore, most occurred within 80 160 min onset, significantly shorter latency onset than In contrast, had incidents or breathing abnormalities during 0.8 gm/kg alcohol. Possible mechanisms for these results are discussed. An provocation test using is proposed evaluation moderate intermittent conditions, but not demonstrating intolerance. The would serve determine influence events, providing patient measure adverse effects social drinking their condition.