Design, synthesis and biological evaluation of selective nonpeptide AT2 receptor agonists and antagonists.
作者： Charlotta Wallinder
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摘要: Migration of the methylene imidazole side chain in first reported selective drug-like AT, receptor agonist C21/M024 (1) delivered antagonist C38/M132 (2). We now report that compound 4, a biphenyl derivative is structurally related to 2, transformed 6 by migration isobutyl group. The importance relative position and substituent highlighted herein.
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