Opening the Way to Gene Activity

作者: E. Pennisi

DOI: 10.1126/SCIENCE.275.5297.155

关键词:

摘要: For decades, molecular biologists have suspected that a chemical modification called acetylation plays an important role in regulating gene activity, but they had trouble proving it. Now researchers several labs identified acetylating and deacetylating enzymes, linked the reaction directly to machinery reads genes: The enzymes turned out be proteins already known associate with transcription factors turn genes on off. What9s more, new work indicates is for cell growth control, when it becomes misdirected, cancer may develop.

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