Aggressive experience increases dendritic spine density within the nucleus accumbens core in female Syrian hamsters.

摘要: Abstract Activity within the mesolimbic dopamine system is associated with performance of naturally motivated behaviors, one which aggression. In male rats, aggressive behavior induces neurochemical changes nucleus accumbens, a key structure system. Corresponding studies have not been done in females. Female Syrian hamsters live as isolates and when sexually responsive are toward either or female intruders, making them an excellent model for studying aggression We took advantage this expressed to examine effects repeated experience on morphology medium spiny neurons accumbens caudate nucleus, utilizing DiOlistic labeling approach. found that significantly increased spine density core, no significant any other brain region examined. At same time, were observed all regions following experience. These data they demonstrate exposure behaviors form part animal’s life history will alter neuronal way may shift neurobiological responses impact future social interactions.