Disposition of diminazene aceturate (Berenil®) in trypanosome-infected pregnant and lactating cows

摘要: Three cows were repeatedly infected with different strains of Trypanosoma congolense and treated intramuscularly each time a dose diminazene aceturate (Berenil). Biphasic decline was observed the maximal plasma drug levels, which attained at 15 min after first treatment 30 second third treatments. The rate constants for distribution terminal phases depended on period exposure to parasitaemia animal treatment. Maximal residue levels found in milk 8 h post declined biexponentially 4.56 ng ml-1 8.76 21 days 3.5 mg kg-1 7.0 doses, respectively. In three cows, higher residues kidney (7.04, 3.92 7.99 micrograms g-1) than liver (3.26, 2.87 1.24 heart (1.79, 1.25 1.03 g-1). results this study indicate that level (degree anaemia) affects distribution, disposition elimination animal. Furthermore, depends could easily be bioavailable consumer.