Thermodynamic aspects of fibroblastic spreading on diamond-like carbon films containing titanium dioxide nanoparticles
作者： F. R. Marciano , C. C. Wachesk , A. O. Lobo , V. J. Trava-Airoldi , C. Pacheco-Soares
DOI: 10.1007/S00214-011-1018-5
关键词:
摘要: The combination of low friction, wear resistance, high hardness, biocompatibility, and chemical inertness makes diamond-like carbon (DLC) films suitable in numerous applications biomedical engineering. cytotoxicity DLC containing TiO2 nanoparticles was practical theoretically evaluated. were grown on 316L stainless steel substrates from a dispersion nanopowder hexane. Raman spectroscopy shows that the presence increased graphite-like bonds films. incorporation into increases surface roughness, decreases water contact angle (increased hydrophilic character), total free energy due to higher polar component. As concentration increased, cell viability (MTT assay), becoming more thermodynamically favorable spreading (ΔF Adh values became negative). This evidenced through increasing number projections (philopodia lamellipodia), indicating adhesion between L929 cells theoretical findings this study show is effective enhancing viability. These results potential use TiO2-DLC applications.
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