A genomic approach to susceptibility and pathogenesis leads to identifying potential novel therapeutic targets in androgenetic alopecia.

摘要: We studied genome-wide gene expression from bald and haired scalp of individuals to evaluate pathogenic mechanisms underlying the development progression androgenetic alopecia (AGA). Unbiased analyses revealed a "bald pathology" based signature. Ontology enrichment differentially expressed genes (DEGs) underscored apoptosis, cell proliferation, perturbed neurological pathways, WNT signaling as central drivers hair loss process. Interactome analysis uncovered several known novel key transcriptional regulators potentially affecting disease pathogenesis both within "hidden" dataset. One DEG mapped one fourteen identified transcriptionally active "hot spots" across genome coincided with previous AGA-associated gene. The remaining DEGs offer an additional set potential linked loci that may help guide future studies aimed at identifying risk genes. Finally, we used in silico identify five molecular targets for exploration AGA therapies.