Suppressing Effects of Feijoa sellowiana Berg (Feijoa) on Cytokine Secretion by Intestinal Epithelium

作者: Mariko MANABE , Yuka ISOBE

DOI: 10.3136/FSTR.11.71

关键词:

摘要: Intestinal mucosal immunity is very important to the body’s defense system and can be affected by extrinsic factors such as bacteria food components. In present report we assessed intestinal immunomodulatory activity of Feijoa sellowiana Berg (feijoa), a tropical fruit expected become widely popular in Japan. We examined effects aqueous extract from feijoa vitro-digested on secretion IL-7 TGF-β Caco-2 cells that are used vitro models epithelium. found both suppressed cells. These results suggest continued intake may induce decrease concentrations lamina propria, which turn cause suppressions oral tolerance disorders homeostasis. Moreover, polyphenols appear involved suppressing effect

参考文章(24)
Thomas Doetschman, Gregory P. Boivin, Peter S. Gartside, Sandra J. Engle, Ilona Ormsby, James B. Hoying, Transforming Growth Factor β1 Suppresses Nonmetastatic Colon Cancer at an Early Stage of Tumorigenesis Cancer Research. ,vol. 59, pp. 3379- 3386 ,(1999)
T.K. Mao, J. Van De Water, C.L. Keen, H.H. Schmitz, M.E. Gershwin, Cocoa flavonols and procyanidins promote transforming growth Factor-β1 homeostasis in peripheral blood mononuclear cells Experimental Biology and Medicine. ,vol. 228, pp. 93- 99 ,(2003) , 10.1177/153537020322800113
Tin Mao, Judy Van de Water, Carl L. Keen, Harold H. Schmitz, M. Eric Gershwin, Cocoa Procyanidins and Human Cytokine Transcription and Secretion Journal of Nutrition. ,vol. 130, ,(2000) , 10.1093/JN/130.8.2093S
M Watanabe, Y Ueno, T Yajima, Y Iwao, M Tsuchiya, H Ishikawa, S Aiso, T Hibi, H Ishii, Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes Journal of Clinical Investigation. ,vol. 95, pp. 2945- 2953 ,(1995) , 10.1172/JCI118002
Ronald G. Binder, Robert A. Flath, Volatile components of pineapple guava Journal of Agricultural and Food Chemistry. ,vol. 37, pp. 734- 736 ,(1989) , 10.1021/JF00087A034
Dirk Haller, Patrik Serrant, Genneviève Peruisseau, Christiane Bode, Walter P. Hammes, Eduardo Schiffrin, Stephanie Blum, IL-10 producing CD14low monocytes inhibit lymphocyte-dependent activation of intestinal epithelial cells by commensal bacteria. Microbiology and Immunology. ,vol. 46, pp. 195- 205 ,(2002) , 10.1111/J.1348-0421.2002.TB02686.X
Yoko FUKE, Ikuko NAGATA, Yoko WATANABE, Toshiko FURUKAWA, Sadako TAKASAKI, Masako NANAYAMA, Hiroatsu MATSUOKA, Hiroshi UEDA, Effects of Cooking Methods of Cabbage on the Production of TNF-α and Induction of Quinone Reductase in Hepa 1c1c7 Cells Food Science and Technology Research. ,vol. 7, pp. 311- 314 ,(2001) , 10.3136/FSTR.7.311
K Bulut, J.J Meier, N Ansorge, P Felderbauer, F Schmitz, P Hoffmann, W.E Schmidt, B Gallwitz, Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro—evidence for a TGF-β-mediated effect Regulatory Peptides. ,vol. 121, pp. 137- 143 ,(2004) , 10.1016/J.REGPEP.2004.04.014