The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
作者： F. P. Siegal
DOI: 10.1126/SCIENCE.284.5421.1835
关键词:
摘要: Interferons (IFNs) are the most important cytokines in antiviral immune responses. “Natural IFN-producing cells” (IPCs) human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated further characterized because of their rarity, rapid apoptosis, lack lineage markers. Purified IPCs here shown to be CD4+CD11c− type 2 dendritic cell precursors (pDC2s), which produce 200 1000 times more IFN than other cells after microbial challenge. pDC2s thus an effector system, critical for antitumor
sciencemag.org
scienceopen.com参考文章(16)
F Deinhardt, H Abb, J Abb, Phenotype of human alpha-interferon producing leucocytes identified by monoclonal antibodies. Clinical and Experimental Immunology. ,vol. 52, pp. 179- 184 ,(1983)
Stuart E Starr, Santu Bandyopadhyay, Vedapuri Shanmugam, Nassef Hassan, Steven Douglas, Stephanie J. Jackson, Jihed Chehimi, Giorgio Trinchieri, Morphological and functional differences between HLA-DR+ peripheral blood dendritic cells and HLA-DR+ IFN-alpha producing cells. Advances in Experimental Medicine and Biology. ,vol. 329, pp. 173- 178 ,(1993) , 10.1007/978-1-4615-2930-9_29
L Borowski, A Logar, C Rinaldo, P Gupta, J Navratil, S Ghanekar, L Zheng, Cytokine expression by human peripheral blood dendritic cells stimulated in vitro with HIV-1 and herpes simplex virus. Journal of Immunology. ,vol. 157, pp. 4028- 4036 ,(1996)
Hans H. Peter, Helga Dallügge, Rainer Zawatzky, Susanne Euler, Wolfgang Leibold, Holger Kirchner, Human peripheral null lymphocytes. II. Producers of type-1 interferon upon stimulation with tumor cells, Herpes simplex virus and Corynebacterium parvum. European Journal of Immunology. ,vol. 10, pp. 547- 555 ,(1980) , 10.1002/EJI.1830100712
K. SANDBERG, M-L. ELORANTA, A. JOHANNISSON, G. V. ALM, Flow cytometric analysis of natural interferon-alpha producing cells. Scandinavian Journal of Immunology. ,vol. 34, pp. 565- 576 ,(1991) , 10.1111/J.1365-3083.1991.TB01580.X
Virus interference. I The interferon Proceedings of The Royal Society B: Biological Sciences. ,vol. 147, pp. 258- 267 ,(1957) , 10.1098/RSPB.1957.0048
Patricia Fitzgerald-Bocarsly, Human natural interferon-α producing cells Pharmacology & Therapeutics. ,vol. 60, pp. 39- 62 ,(1993) , 10.1016/0163-7258(93)90021-5
S.B. Feldman, M. Ferraro, H-M Zheng, N. Patel, S. Gould-Fogerite, P. Fitzgerald-Bocarsly, Viral Induction of Low Frequency Interferon-α Producing Cells Virology. ,vol. 204, pp. 1- 7 ,(1994) , 10.1006/VIRO.1994.1504
H. SVENSSON, A. JOHANNISSON, T. NIKKILÄ, G. V. ALM, B. CEDERBLAD, The Cell Surface Phenotype of Human Natural Interferon-α Producing Cells as Determined by Flow Cytometry Scandinavian Journal of Immunology. ,vol. 44, pp. 164- 172 ,(1996) , 10.1046/J.1365-3083.1996.D01-289.X
Piotr Chomczynski, Nicoletta Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Analytical Biochemistry. ,vol. 162, pp. 156- 159 ,(1987) , 10.1016/0003-2697(87)90021-2