Tumor-Localized Insult Delivered by Photodynamic Therapy and the Breakdown of Tumor Immunotolerance
作者： Mladen Korbelik
DOI: 10.1007/978-94-007-4694-7_7
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摘要: Photodynamic therapy (PDT) is a clinically established modality for the treatment of cancerous and other diseased tissue by localized activation of a photoreactive drug with light to generate cytotoxic reactive oxygen species in targeted lesions. The nature of insult inflicted on tissue by PDT classifies it with cancer therapies including hyperthermia, cryoablation, and electric field ablation, which produce a prompt trauma at the treated site and rapid dramatic changes in tumor microenvironment. This type of insult (regardless that it …
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