Use of Computational Fluid Dynamics to Analyze Blood Flow, Hemolysis and Sublethal Damage to Red Blood Cells in a Bileaflet Artificial Heart Valve

摘要: Artificial heart valves may expose blood to flow conditions that lead unnaturally high stress and damage cells as well issues with thrombosis. The purpose of this research was predict the trauma caused red (RBCs), including hemolysis, from stresses applied them their exposure time determined by analysis simulation results for through both a functioning malfunctioning bileaflet artificial valve. calculations provided spatial distribution Kolmogorov length scales were used estimate size distributions smallest turbulent eddies in field. number surface area these utilized amount hemolysis experienced RBCs. Results indicated levels are low while suggesting at leading edge leaflet contribute subhemolytic characterized shortened circulatory lifetimes reduced RBC deformability.