Ventilatory and arousal responses to hypoxia in sleeping humans.

摘要: We measured ventilatory and arousal responses to progressive eucapnic hypoxia during wakefulness, nonrapid-eye-movement (NREM) sleep, rapid-eye-movement (REM) sleep using a isocapnic rebreathing method. Nine healthy adults (4 female, 5 male) slept with mask glued the face medical silicone rubber breathed from closed valveless biased flow circuit, including an in-line bag-in-box variable soda-lime absorber. Progressive was induced by consumption of oxygen gradual replacement circuit volume nitrogen. Tidal electrical integration signal pneumotach on box. Arterial hemoglobin saturation (SaO2) ear oximeter end-tidal CO2 tension (PetCO2) continuously kept constant absorption. Sleep state identified standard criteria 2 channels each EEG, submental EMG, EOG. There marked variability in level both NREM REM s...