NADPH Oxidases as Regulators of Tumor Angiogenesis: Current and Emerging Concepts
作者： Sanja Coso , Ian Harrison , Craig B. Harrison , Antony Vinh , Christopher G. Sobey
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摘要: Abstract Significance: Reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and peroxynitrite are generated ubiquitously by all mammalian cells have been understood for many decades inflicting cell damage causing cancer oxidation nitration of macromolecules, including DNA, RNA, proteins, lipids. Recent Advances: A current concept suggests that ROS can also promote signaling pathways triggered growth factors transcription ultimately regulate proliferation, differentiation, apoptosis, which important hallmarks tumor proliferation angiogenesis. Moreover, an emerging indicates the functions immune infiltrate environment stimulate angiogenesis, macrophages specific regulatory T cells. Critical Issues: In this article, we highlight NADPH oxidase family ROS-generating enzymes key sources and, thus, play role in ...
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