Efficacy of electroconvulsive therapy in treatment-resistant schizophrenia: a prospective open trial

摘要: There is a lack of controlled trials examining the effectiveness electroconvulsive therapy (ECT) combined with olanzapine or risperidone in treatment-resistant schizophrenia (TRS). The authors conducted prospective, open, trial ECT TRS long-term psychiatric rehabilitation unit Hong Kong. Thirty patients from an inpatient participated this study. All subjects were resistant to host antipsychotic medications given singly different combinations. In addition, they also refused clozapine treatment. Fifteen completed course consisting 8-20 sessions. who formed control Subjects assessed at baseline, 1 week, month, and 2 months after their last ECT. Assessment instruments included Brief Psychiatric Rating Scale (BPRS), Hamilton Depression (HDRS), for Negative Symptoms (SANS), Global (GAS), Clinical Impression (CGI), CGI Severity Illness [CGI(SOI)], Improvement [CGI(GI)], Nurses' Observation Inpatient Evaluation (NOSIE-30), occupational therapists' rating subjects' functioning respect work (OT-W), social (OT-S), leisure (OT-L) activities. comparison group, group showed statistically significant improvement only GAS each posttreatment evaluation. was trend reduce positive negative symptoms, although rate did not reach levels. augmentation marginal efficacy compared reports greater these antipsychotics other agents.