Cyanidin-3-O-glucoside functions like chemical chaperone and attenuates the glycation mediated amyloid formation in albumin
作者： Govindarajan Prasanna , Pu Jing
DOI: 10.1016/J.ABB.2018.02.012
关键词:
摘要: In this study, chemical chaperone like function of cyanidin-3-O-glucoside (C3G) was investigated through fluorescence spectroscopy, UV-visible circular dichroism confocal microscopy, scanning electron microscopy and molecular docking studies. Early advanced glycation inhibitory effect evaluated by spectroscopy agarose gel electrophoresis. Amyloids were based on their propensity to bind Congo Red (CR) Thioflavin T (ThT) multiple microscopic approaches. Circular studies used analyze the changes in secondary structure due glycation. C3G effectively inhibited early masking function, carbonyl scavenging activity. had interaction with Glu186, Arg427, Ser428, Lys431, Arg435, Arg458 BSA. Based analysis, it is evident that can inhibit protein aggregation amyloid formation. suggested resulted augmented β-sheet propensity, whereas a protective helical conformation We conclude has event mediated formation
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