Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation
作者： Paul S. Pearlman , Adriana Leonora Botes , Alex van Eck Conradie , Changlin Chen
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摘要: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic 7-hydroxyheptanoic heptamethylenediamine and 1,7-heptanediol by forming two terminal functional groups, comprised carboxyl, amine hydroxyl in a C7 aliphatic backbone substrate produced from succinate semialdehyde pyruvate. These pathways, metabolic engineering cultivation strategies described herein rely on the aldol condensation
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