3.312 – Cell Culture Systems for Studying Biomaterial Interactions with Biological Barriers

摘要: The human body has numerous physical barriers that prevent most harmful or foreign compounds from entering the body. These are formed by unique cell types, which through their location-specific biological characteristics passing between them selectively allow only specific to move across barrier they form. Multiple types involved together form functioning in a particular organ tissue. In many cases, vitro multicellular culture systems have been developed. models extremely valuable determining toxic effects of novel on cellular functions and studying mechanisms formation, uptake localization within cell, as well cell–cell interactions. Moreover, represent major hurdle for micro- nanoparticle biomaterials designed drug gene delivery purpose this chapter is present an overview important describe detail coculture upper lower respiratory units lung, skin study blood–brain barrier. How these mimic natural tissue, what criteria used validate models, how model can be applied biomaterials, especially nanoparticulate form, described.