The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex.

摘要: STUDY DESIGN: This study examined the differences in tactile hypersensitivity across 6 different strains of male mice, and between female rats 3 a rodent model low back pain associated with lumbar radiculopathy. OBJECTIVE: We investigated possibility that allodynia following same nerve root injury are affected by genotype sex rodents. SUMMARY OF BACKGROUND DATA: Low radiculopathy affects countless people throughout world, encompassing wide range individual susceptibility. The roles genetics on nociceptive sensitivities have yet to be fully characterized. METHODS: Six mice (BALB/cJ, CBA/J, C57BL/6J, 129P3/J, C3H/HeJ, C58/J; all males) Sprague Dawley, Holtzman, Long-Evans underwent followed assessment allodynia. RESULTS: most sensitive mouse were: C58/J, BALB/cJ; less CBA/J. Female Dawley displayed increased compared males. No were observed Holtzman rats. CONCLUSIONS: Different strains, exposed identical injuries diverse levels hypersensitivity, supporting hypothesis genetic factors play key role radicular pain. Our results correlate data compiled rat after L5-L6 ligation, suggesting precise nature is not relevant inheritance neuropathic symptom sensitivity.