Aminoacids in the Synthesis of Heterocyclic Systems: The Synthesis of Triazinoquinazolinones, Triazepinoquinazolinones and Triazocinoquinazolinones of Potential Biological Interest
作者： A. El-Sharief , Y. Ammar , M. Zahran , A. Ali , M. El-Gaby
DOI: 10.3390/60300267
关键词:
摘要: Abstract: A number of novel triazinoquinazolinones ( 5b,c and 8) , triazepinoquinazoli-nones( 5a, 6b, 7 9) triazocinoquinazolinones 6a 10) were obtained vianucleophilic interaction 3-aminoquinazolinone derivatives 3 with different reagents. Keywords: Triazinoquinazolinones, triazepinoquinazolinones, triazocinoquinazolinones,biological activity Introduction Varied biological activities have been attributed to quinazoline compounds, including analgesic,antiinflammatory, antipyretic [1-3], antimicrobial [4], anticonvulsant [5], fungicidal [6], anti-depressant other central nervous system affecting [7]. The use aminoacids as startingmaterials for the design synthesis new compounds aim preparingpotent biologically active is a subject recent interest [8-11]. Now we report facilesynthesis several heterocyclic containing six, seven eight membered rings fused toa moiety starting from amino acids.
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