Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response.

摘要: Abstract Aim Studies characterizing treatment interventions in a naturalistic setting suggest that antidepressant and antipsychotic medications may be equally effective improving clinical outcome individuals at high risk for first-episode psychosis. Of interest, both beneficial as well potentially adverse effects have been observed following fluoxetine mouse prenatal immune activation model of relevance to psychosis prevention. We sought extend those findings by examining the fluoxetine, medication aripiprazole, rat model. Methods Pregnant Sprague–Dawley rats were injected with poly I:C or saline on gestational day 14. Offspring saline-treated dams received (10.0 mg/kg/d), aripiprazole (0.66 mg/kg/d), vehicle from postnatal days 35 70. Locomotor responses novelty, injection, amphetamine (1 5 mg/kg) determined three months, i.e., 21 days drug discontinuation. Results Both had behavioral response (1 mg/kg) 3 months, ameliorating impact offspring I:C-treated dams. Significantly, drugs also exerted control (saline-treated) locomotor injection. Conclusions Fluoxetine pretreatment 70 stabilized exposure persisting through 3 months age, similar earlier mice prevented altered amphetamine. The current data confirm potential medications, highlighting therapeutic safety concerns preventive pharmacological treatments over course adolescent development. Further study is needed determine epidemiological consequences these pre-clinical findings.