Sintered porous DP-bioactive glass and hydroxyapatite as bone substitute.

摘要: Abstract There is extensive experimental and surgical experience with the use of bone tissue to fill defects in skeleton, bridge non-union sites, pack created from cyst curettage. DP-bioactive glass a chemical composition Na 2 O 8.4%, SiO 39.6%, P 0 5 12% CaO 40% has been reported as an alternative substitute high mechanical strength, good biocompatibility which tight bond living tissue. The bonding layer between was considered be formed by dissolution calcium phosphate ions into surrounding body fluids. biological hydroxyapatite suspected deposit directly onto layer. In order confirm interaction tissue, developed bioactive implanted rabbit femur condyle for 2–32 weeks. histological evaluation also investigated study. Porous bioceramic used control group results were compared those glass. interface examined SEM-EPMA showed that reaction on surface within weeks after operation direct natural bone. elements contained apparently interdiffuse deposited diffusion area, proved EPMA TEM. After implantation over 8 weeks, gradually biodegraded absorbed Histological examination using optical microscope osteocytes grow inside would expected part Biomaterials (1994) 15 , (13) 1087–1098